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You should not use the information contained here for diagnosing or treating a health problem or disease.
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Metformin may be used with lifestyle changes such as diet and exercise to prevent in people who are at high risk for becoming diabetic.

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If you eat low carbohydrate meals, metformin weight loss will be much more effective.

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Click on citations within drug and disease topics in our clinical reference to review the clinical evidence on MEDLINE.

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Effect of metformin on food intake in obese subjects.

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The main goals in diabetes management are controlling blood glucose levels and preventing long term complications, such as cardiovascular disease, kidney disease, nerve damage and diabetic retinopathy, a serious complication of the eye.

Six months of adjunctive metformin therapy does not improve glycemic outcomes in overweight adolescents with type 1 diabetes, according to new research from T1D Exchange and funded by the JDRF.

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It also found that glucose uptake in muscles by metformin required the activation of AMPK.

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Although there is some evidence that a tolerance can build up with any medication, metformin (brand name Glucophage) is well tolerated for long periods of time.

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Kidney disease, liver disease and alcohol intake can contribute to increased levels of metformin which can result in an increased concentration of lactic acid in the body.

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Treatment guidelines for major professional associations including the European Association for the Study of Diabetes, the European Society for Cardiology, and the American Diabetes Association, now describe evidence for the cardiovascular benefits of metformin as equivocal.

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Metformin can be prescribed to assist in weight loss for a non-diabetic but it isn't a common practice and would be an off-label use in the US.

You should not take this medicine if you become pregnant or think you may be pregnant.

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GLUCOPHAGE plus insulin versus insulin plus placebo was conducted in patients with type 2 diabetes who failed to achieve adequate glycemic control on insulin alone (see Table 5).

Met XR dose was titrated over 3 weeks; no other treatments were titrated.

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